Heterotopic Gray Matter
Last Updated: October 1, 2018
- Disrupted migration of neurons from periventricular germinal zone to the cortex
- Periventricular nodular type
- FLNA gene commonly involved on Xq28
- Band like heterotopia/lissencephaly
- Deletion of LIS1 on 17p13.3 or DCX on Xq22.3-q23
- Young child with variable developmental delay and seizures
- Severe cases present earlier in life
- Typically present by the 3rd decade of life
- M > F
- Males have worse outcomes
- Abnormal gray matter nodules or ribbons within the white matter anywhere from ventricles to cortex
- Modality Specific
- CT and MR
- Nonenhancing masses that follow the density or intensity of gray matter on all images
- CT and MR
- Imaging Recommendations
- MR with contrast
- Low grade gliomas may have a similar appearance, but usually do not match gray matter so closely on all MR sequences.
For more information, please see the corresponding chapter in Radiopaedia.
Contributor: Sean Dodson, MD
Barkovich AJ. Morphologic Characteristics of Subcortical Heterotopia: MR Imaging Study. AJNR. 2000; 21:290-95.
Barkovic AJ and Kjos BO. Gray Matter Heterotopias: MR Characteristics and Correlation with Developmental and Neurologic Manifestations. Radiology. 1992; 182(2):493-99.
Donkol RH, et al. Assessment of Gray Matter Heterotopia by Magnetic Resonance Imaging. World J Radiol. 2012; 4(3):90-6.
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