OBJECT The two most common surgical routes to the fourth ventricle are the transvermian and telovelar approaches. The purpose of this study was to compare the microanatomy and exposures gained through these approaches.
METHODS Ten formalin-fixed specimens were dissected in a stepwise manner to simulate the transvermian and telovelar surgical approaches. Stealth image guidance was used to compare the exposures and working angles obtained using these approaches.
The transvermian and telovelar approaches provided access to the entire rostrocaudal length of the fourth ventricle floor from the aqueduct to the obex. In addition, both approaches provided access to the entire width of the floor of the fourth ventricle. The major difference between the two approaches regarded the exposure of the lateral recess and the foramen of Luschka. The telovelar, but not the transvermian, approach exposed the lateral and superolateral recesses and the foramen of Luschka. The transvermian approach, which offered an incision through at least the lower third of the vermis, afforded a modest increase in the operator’s working angle compared with the telovelar approach when accessing the rostral half of the fourth ventricle.
CONCLUSIONS The transvermian approach provides slightly better visualization of the medial part of the superior half of the roof of the fourth ventricle. The telovelar approach, which lacks incision of any part of the cerebellum, provides an additional exposure to the lateral recesses and the foramen of Luschka.
The two most common surgical approaches to the fourth ventricle are the transvermian and telovelar approaches. The first involves incising the inferior vermis of the cerebellum and retracting the two halves of the vermis in opposite lateral directions.1,3,6,11,12 In the second approach, the tela choroidea and inferior medullary velum, which form the lower half of the roof of the fourth ventricle, are opened and the lower vermis is retracted as a unit to provide exposure into the fourth ventricle.17,20,22 The technical differences between the two approaches and the anatomical structures that limit the surgical view in each approach result in differences with regard to the exposure of the fourth ventricle floor, the lateral recess, and the foramen of Luschka. The purpose of this study was to describe and compare the microanatomical features of the transvermian and telovelar approaches and to relate these features to the exposure gained through each approach.
Materials and Methods
Ten formalin-fixed specimens, in which the arteries had been perfused with red silicone and the veins with blue silicone, were examined in this study. The specimens were dissected in a stepwise manner, with the aid of an operating microscope set to 3 to 40, to simulate exposures that can be obtained using the transvermian and telovelar approaches. Special attention was directed to the anatomical structures that limit visualization in each approach.
Three of 10 cadaveric heads were studied using MR imaging, and the data were registered on a Stealth workstation by using standard protocols. Magnetic resonance images were obtained using a 3-tesla MR imaging system (Magnetom Allegra; Siemens Medical Solutions, Malvern, PA) and transferred to a Stealth Image Guidance workstation (Medtronic Surgical Navigation Technologies, Louisville, CO). Ten fiducial markers used for image registration were attached to the skin overlying the superior sagittal sinus and the parietooccipital area. The head was placed similar to the orientation provided by the semisitting position and a suboccipital craniotomy was performed through a midline vertical skin incision. A 3D model was built and a dynamic reference array was attached to the cadaver. The specimen was registered to the 3D model and image, resulting in an estimated accuracy of better than 2 mm. An active probe was used to indicate the surgical exposure on the 3D model and on three orthogonal MR images. These images were recorded through screen captures. The superior, inferior, lateral, superolateral, and foramen of Luschka exposures through each approach to the fourth ventricle were determined using image guidance under direct microscopic visualization.
We compared the operative angle of approach through the transvermian and telovelar routes. The angle was measured from the floor of the fourth ventricle in the sagittal plane. The apex of the angle was placed at three sites along the ventricle floor: the aqueduct, the midpoint (50% point) of the distance measured from the obex to the inferior border of the aqueduct, and the point 75% of the same distance.
Operative approaches to the fourth ventricle move through the suboccipital or posterior surface of the cerebellum, which is located below the transverse sinus and between the sigmoid sinuses. The vermis is folded into and forms the suboccipital cortical surface within the posterior cerebellar incisura, which is a deep vertical depression on the posterior surface of the cerebellum (Fig. 1). The vermian surface within the posterior cerebellar incisura has a shape similar to that of a diamond, the upper portion of which is called the pyramid. The lower half of the vermian surface projects downward between the tonsils and is called the uvula, thus mimicking the anatomy found in the oropharynx (Fig. 1). The medial margin of the rostral portion of the tonsils borders the tapering edges of the uvula. The strip of vermis within the incisura is broadest at the junction of the pyramid and uvula. Inferiorly, the posterior cerebellar incisura is continuous with the vallecula, a cleft between the tonsils that opens into the foramen of Magendie.
The tonsils, the most prominent structures blocking access to the caudal portion of the fourth ventricle, are considered hemispherical components. The tonsils are ovoid structures, which, along their superolateral borders, are attached to the remainder of the cerebellar hemisphere, whereas the remaining parts of each tonsil are free surfaces (Fig. 1). The anterior and medial surfaces of each tonsil are important landmarks that are recognizable when approaching the fourth ventricle. The anterior surface faces the cerebellomedullary fissure, which is a cleft between the tonsil and the posterior surface of the medulla oblongata. The medial surfaces of the tonsils face each other across a narrow cleft, the vallecula, which leads into the inferior portion of the floor of the fourth ventricle.
The roof of the fourth ventricle is a tent-shaped structure. The apex of the roof, the fastigium, is the site of the roof’s greatest height and width. The fastigium divides the roof into superior and inferior portions. The superior half of the roof expands laterally and posteriorly from the aqueduct to the level of the fastigium and lateral recess (Figs. 2 and 3). The superior half of the roof is formed medially by the superior medullary velum, which connects at the fastigium with the inferior medullary velum and laterally with the inner surfaces of the superior and inferior cerebellar peduncles. The fibers of the superior cerebellar peduncle arise in the dentate nucleus and ascend to form the ventricular surface of the superior portion of the lateral wall (Fig. 3).
The inferior portion of the roof is formed by the tela choroidea and the inferior medullary velum (Figs. 2 and 4). The inferior medullary velum is a membranous remnant of the connection between the nodule and the folliculi that forms the flocculonodular lobe.9 It is a thin bilateral layer of neural tissue that extends from the nodule medially and blends into the dorsal margin of each lateral recess, forming the peduncle of each flocculus laterally (Figs. 2 and 4). Caudally, the inferior medullary velum attaches to the tela choroidea. The tela choroidea contains a vascular layer of choroidal arteries and veins between its layers and the choroid plexus projects from its ventricular surface (Fig. 4). Importantly, no known functional neural tissue resides within the structures that form the inferior portion of the roof of the fourth ventricle.
The telovelar junction, the line of attachment of the inferior medullary velum to the tela choroidea, extends laterally from the nodule into each lateral recess (Fig. 4). The tela attaches to the inferolateral edges of the floor along narrow ridges, the taeniae, which meet at the obex. The tela choroidea has three openings to the subarachnoid recess: the paired foramina of Luschka, located at the lateral recess, and the foramen of Magendie, located medially at the caudal end of the fourth ventricle (Fig. 4).
Cerebellomedullary Fissure and Its Vascular Relations
The inferior half of the roof of the fourth ventricle is intimately related to the cerebellomedullary fissure. The fissure has ventral and dorsal walls. The ventral wall is formed by the posterior surface of the medulla, the inferior medullary velum, and the tela choroidea (Fig. 1). The dorsal wall is formed by the uvula, tonsils, and biventral lobules. The cerebellomedullary fissure extends superiorly to the level of the lateral recess and is continuous with the fourth ventricle through the foramen of Magendie and the cisterna magna around the superior surface of the tonsils; the fissure communicates with the cerebellopontine fissure by way of the foramina of Luschka (Fig. 4).
The PICA is intimately related to the cerebellomedullary fissure, the inferior half of the roof of the fourth ventricle, and the suboccipital surface. The PICA arises from the vertebral artery at the anterolateral margin of the medulla oblongata, close to the lower cranial nerves, and courses through a series of deep fissures that lie among the tonsil, vermis, and cerebellar hemisphere (Fig. 1). The PICA is divided into five segments: the anterior medullary, lateral medullary, tonsillomedullary, telovelotonsillar, and cortical segments.15 The PICA segment that is most commonly exposed during the transvermian and telovelar approaches is the telovelotonsillar segment, which courses in the cleft that lies between the tonsil (below) and the tela choroidea and velum (above). The PICAs bifurcate into medial and lateral trunks in their passage around the tonsil (Fig. 1). The medial trunk supplies the vermis and the lateral trunk supplies most of the hemispherical and tonsillar surfaces. Both trunks are frequently encountered during approaches to the fourth ventricle.
The vein of the cerebellomedullary fissure is the largest vein crossing the inferior portion of the fourth ventricle. It originates on the lateral edge of the nodule and uvula, courses laterally along the telovelar junction, and passes caudal to the cerebellar peduncles to reach the cerebellopontine angle. It drains into veins that empty into the superior petrosal sinus.18 The tributaries of the vein of the cerebellomedullary fissure drain portions of the tonsil, inferior vermis, inferior medullary velum, tela choroidea, and attached choroid plexus, as well as the ventricular white matter and dentate nuclei.
Floor and Lateral Recesses
The floor of the fourth ventricle, a rhomboid structure is situated with its rostral two thirds posterior to the pons and its caudal one third posterior to the medulla oblongata (Figs. 2 and 4). Its cranial apex is at the level of the cerebral aqueduct, and caudally it ends at the obex, which lies anterior and deep with respect to the foramen of Magendie. The intermediate portion of the floor of the fourth ventricle extends into the lateral recesses. The vestibular area, the portion of the floor lateral to the median eminence and sulcus limitans, is located at the lateral limit of the floor of the fourth ventricle (Fig. 3). The vestibular nuclei lie beneath the vestibular area, which forms a rounded elevation that extends directly into the lateral recess. Rostral to the vestibular area, the striae medullaris course transversely from the region of the lateral recess across the inferior cerebellar peduncle toward the midline (Fig. 3).
The fourth ventricle is continuous with the cerebellopontine angle through the foramen of Luschka at the lateral recess, which is a narrow pouch formed by the union of the roof and the floor (Fig. 4). The ventral wall of each lateral recess is formed by the junctional portion of the floor and the rhomboid lip, a sheetlike layer of neural tissue. The rostral part is formed by the caudal margin of the cerebellar peduncles. The caudal part of each lateral recess is formed by the tela choroidea, which extends from the lateral part of the taenia to the flocculus (Fig. 4).
The oldest and most widely used surgical approach to the fourth ventricle consists of splitting the inferior vermis on the suboccipital surface.1,11,12 The extent of the incision through the inferior vermis has been poorly described. The incision extends a variable distance through the uvula, pyramid, tuber, and folium of the vermis, depending on the location and size of the pathological area. Most authors advocate limiting the vermian incision to the smallest possible length necessary to gain access to avoid complications associated with splitting the vermis.23 Similarly, a transvermian incision through the inferior vermis and extending into the fourth ventricle was performed in our study. We maximized the transvermian incision to include the inferior vermis up to the fastigium, but did not extend it into the inferior edge of the superior medullary velum. Functionally, the decussating fibers of the superior cerebellar peduncle lie deep in relation to the superior medullary velum, which is a thin lamina of white substance between the superior cerebellar peduncles. The vermian incision exposed the underlying nodule, which was necessarily incised along with the tela choroidea and inferior medullary velum to gain access to the fourth ventricle (Fig. 5).
Retraction of the two halves of the lower vermis provided approximately 1 to 2 cm of working space between the two edges of the inferior vermis. Following the retraction of the vermis and tonsils laterally, it was possible to follow the course of the telovelotonsillar segments of the bilateral PICA and work in between the right and left segments without sacrificing any of the major branches of the vessels (Fig. 5). The vein of the cerebellomedullary fissure coursed horizontally at the site of the midline vermian incision along the tela choroidea and inferior medullary velum in three hemispheres (Fig. 5). After the the tela choroidea and inferior medullary velum had been opened through a midline incision, the full length of the floor (mean length 4 cm) from the aqueduct to obex, could be exposed (Fig. 5). Laterally, the limit of exposure was maximal at the level of the striae medullaris. The initial medial portion of the vestibular area was the lateral limit of exposure. Superiorly, the middle portion of the superior medullary velum was the limit of exposure. At this point in the dissection, exposure of the lateral recess and the foramen of Luschka was not possible in any of our specimens by using the transvermian approach. Exposure of the lateral recess requires removal of a portion of the vermis, whereas exposure of the foramen of Luschka requires additional retraction of the tonsillar pole.3,13
Stealth image guidance was introduced into the dissection field after we obtained maximal exposure through the fourth ventricle (Fig. 5). The mean operative angles of the transvermian approach measured at three locations along the floor of the fourth ventricle were 38 ̊ at the aqueduct, 84 ̊ at the midpoint of the distance from the obex to the aqueduct, and 72 ̊ at the 75% point. The superior medullary velum was the main anatomical structure limiting the working angle in the sagittal plane. The limitation was most significant when we exposed the rostral one fourth of the fourth ventricle, and the operative view decreased when we moved in the mediolateral direction. The fastigium and the inferior portion of the superior medullary velum limited the working angle at the point 75% of the distance between the obex and aqueduct. At the midpoint along the length of the floor of the fourth ventricle, the working angle increased dramatically. At this point, the exposure was limited superficially at the level of the superior limit of the vermian incision.
Following exposure of the suboccipital surface of the cerebellum, the uvulotonsillar and medullotonsillar spaces on both sides were opened along with the lateral and deep dissection around the surfaces of the tonsil and the biventral lobule without dividing any neural tissue (Figs. 6–8). The inferior edge of the tonsils was exposed and the dissection extended between the medial side of the tonsil and the adjacent edge of the uvula. The surface of the tonsil that faced the uvula was retracted superolaterally toward the side of the approach, and the uvula was retracted to the opposite side to expose the inferior medullary velum and tela choroidea. Special attention was directed to the location and bifurcation of the PICA into medial and lateral trunks. The PICA bifurcation was exposed near the inferior end of the uvulotonsillar space, around the telovelar junction, in three of the 10 specimens. If the bifurcation was present along the site of incision, it was easier to retract it laterally than medially before we made the incision along the tela and inferior medullary velum (Figs. 6 and 8).
The telovelar incision can be divided in three parts. The first part of the incision, which opens the tela choroidea, begins inferiorly near the foramen of Magendie in the lower portion of the ventricle roof and extends upward to the level of the junction of the tela with the inferior medullary velum (Fig. 6). After we opened the tela choroidea, the full length of the floor of the fourth ventricle came into view in some hemispheres. The second part involves extending the incision superiorly through the inferior medullary velum, which is exposed in the depths of the uvulotonsillar space. The vein of the cerebellomedullary fissure, which crosses the inferior medullary velum, was transected in some specimens. Incising the inferior medullary velum exposed the ipsilateral superolateral recess and provided access to the entire floor of the fourth ventricle in all hemispheres (Figs. 6 and 8). Opening the inferior medullary velum also increased the exposure of the lower portion of the superior medullary velum near the fastigium. Opening the tela and the inferior medullary velum through the uvulotonsillar space on one side provided limited exposure to the lateral portion of the opposite half of the floor; however, shifting the exposure to the opposite uvulotonsillar space and opening the tela and velum provided an identical exposure to that obtained on the other side. The third incision, which was directed between the tonsil and medulla oblongata through the tela forming the lower posterior wall of the lateral recess, provided additional access to the full length of the lateral recess and the foramen of Luschka (Fig. 8).
Stealth image guidance was used to demonstrate the anatomical exposure gained through the telovelar approach (Figs. 7 and 9). The mean operative angles for the telovelar approach at the three sites along the floor of the fourth ventricle were 30 ̊ at the aqueduct, 67 ̊ at the 75% point, and 84 ̊ at the midpoint. The main limitations of the exposure through this approach were the superior medullary velum and the junction between the pyramid and uvula (Figs. 7–9). The junction of the uvula and pyramid, the broadest strip of vermis within the posterior incisural space, limited the lateral and medial retractions of the tonsil and the uvula at the uvulotonsillar space, respectively (Figs. 3 and 8). The operative angle was limited by the uvulopyramidal junction in all specimens during the telovelar approach.
In both the transvermian and telovelar approaches, the operative angle of approach was limited by the superior medullary velum, which does not appear to be a uniform structure when one moves in a mediolateral direction. The superior medullary velum forms a larger angle with the floor of the fourth ventricle in the midline than it does laterally. In the telovelar approach, the fourth ventricle is approached off the midline through the superolateral recess, which accounts in part for the decrease in operative angle. The mean differences between the operative angles of the two approaches did not exceed 8 ̊ in favor of the transvermian approach.
The transvermian and telovelar approaches provide excellent exposure of the entire floor of the fourth ventricle. The transvermian approach, performed using a midline vermian incision, provided a slightly better exposure of the midline superior half of the roof of the fourth ventricle and fastigium. The telovelar approach provided additional access to the lateral recesses and foramen of Luschka in all specimens.
Approaching the fourth ventricle presents challenges because of its deep location and relationship to vital structures of the brainstem. The transvermian approach has been the most commonly used means to access lesions of the fourth ventricle.3,11,12 An alternative approach directed through the cerebellomedullary fissure to the tela choroidea and inferior medullary velum provides an additional means to access the fourth ventricle and has been used by an increasing number of neurosurgeons.8,16,17,20,21,28 Although there are a few reports in the literature on the microsurgical anatomy of the telovelar approach and its clinical applications,8,20,28 its comparison with the more traditional transvermian approach has not been studied.
A common misconception regarding the telovelar approach is that approaching lesions extending into the upper half of the fourth ventricle is difficult due to a reduced working angle and limited exposure of the region. The goal of the present study was to compare the transvermian and telovelar approaches with regard to working angles and anatomical structures limiting the exposure.
Since Dandy’s statement3 regarding splitting of the vermis without causing a disturbance in function, the transvermian approach with a vermian split has been used extensively.14,25 Nevertheless, the transvermian approach requires an incision into the cortical and functional areas of the cerebellum. The splitting of the inferior cerebellar vermis may cause caudal vermis syndrome, resulting in an equilibratory disturbance with truncal ataxia, gait disturbance, oscillation of the head and trunk, and nystagmus.6,7 Moreover, because the dentate nucleus is located along the posterolateral margin of the roof of the fourth ventricle adjacent and rostral to the superior pole of the tonsil, this nucleus may be damaged when splitting the cerebellar vermis.28 When the dentate nucleus is damaged, the equilibratory disturbances that are created are more severe than those observed with vermian lesions alone and are often accompanied by intentional tremor during voluntary movement of the extremities. Splitting the inferior portion of the vermis may also play a role in cerebellar mutism, a transient complication following the removal of a cerebellar and fourth ventricle tumor. Although the exact anatomical substrate for cerebellar mutism remains unknown, the inferior portion of the vermis, including the pyramid, uvula, and nodule, has been implicated.2,4,5,21,24
The use of natural clefts in the cerebellomedullary fissure to approach the fourth ventricle began after a detailed description of the microsurgical anatomy of the region had been published.17,19 Yasargil26,27 described a median inferior suboccipital approach along the “tonsilouveal” sulcus to treat fourth ventricle lesions; however, the use of the cerebellomedullary fissure to access the fourth ventricle without splitting the vermis was first reported by Matsushima, et al.16 Subsequently, this method and satisfactory results were reported by different authors.10,28 The senior author (A.L.R.) has been using the telovelar approach in his practice for more than two decades and has observed no clinical deficit resulting from the opening of the tela and velum. We have recently described the means of exposing the fourth ventricle through the telovelar approach.20
The transvermian and telovelar approaches are distinct from each other in several key aspects. These distinguishing features include the direction and route of the approach, the structures retracted and sacrificed, the direction of the retraction, the structures limiting the exposure, and the areas exposed. The location and direction of the growth of a fourth ventricle or a brainstem lesion play a role in the selection of the ideal approach. Lesions located predominantly in the vermis and extending into the fourth ventricle are accessed by following the transvermian approach. Tumors located on the ependymal surface and in the floor of the fourth ventricle often do not invade the cerebellum and can be accessed using the telovelar approach. Tumors of the fourth ventricle not infrequently extend to the lateral recess, which can be best approached by elevating the ipsilateral tonsil and using the telovelar route. The transvermian incision has the advantage of being in the midline, but gentle retraction of the uvula to the opposite side places the telovelar approach very near the midline. The obex, the posteromedian sulcus of the medulla oblongata, and the foramen of Magendie at the lower edge of the telovelar and transvermian exposures provide landmarks valuable in orienting the operative view to the midline.
The transvermian approach provides a slightly greater working angle in the sagittal plane when approaching the rostral one fourth of the floor of the fourth ventricle. In addition, a slightly better visualization of the midline inferior portion of the superior medullary velum and fastigium is obtained through the transvermian approach. Nevertheless, the main disadvantage of the transvermian approach is a limited lateral exposure. The lateral limit of exposure is the initial portion of the vestibular area along the floor of the fourth ventricle in the transvermian approach, and the lateral recesses cannot be accessed unless part of the vermis or the tonsils is removed. Another drawback to the transvermian approach is the potential for complications due to iatrogenic neural injury caused by the vermian incision, removal of the vermis or tonsils, and the retraction of two halves of the split vermis.
Matsushima, et al.,17 recently reported on the methods of dissecting the cerebellomedullary fissure and proposed three different opening procedures for the transcerebellomedullary fissure approach: extensive, lateral wall, and lateral recess types of procedures. Following the complete dissection of uvulotonsillar and medullotonsillar spaces, we were able to obtain maximum exposures by using a similar set of incisions. Our initial incision was located along the tela choroidea, adjacent to the taenia, extending superolaterally to the telovelar junction. The opening of the tela was followed by an incision along the inferior medullary velum and the posterior margin of the wall of the lateral recess. The telovelar approach exposes the full extent of the floor of the fourth ventricle in a manner similar to the transvermian approach. In addition, the superolateral recess and structures along the lateral recess, including the foramen of Luschka, can be accessed without removal of brain or adjustment of retractors.
A limitation of exposure and a decrease in the working angle due to two anatomical structures can be expected at the inferior portion of the superior medullary velum near the fastigium. This limitation is due, in part, to the fact that the superior medullary velum forms a more narrow angle to the fourth ventricle floor in its lateral aspect when compared with the midline. In addition, the uvulopyramidal junction located at the rostral end of the uvulotonsillar space limits exposure. The superior medullary velum and the uvulopyramidal junction limited the working angles at the aqueduct and the 75% point along the floor of the fourth ventricle. The difference between the working angles of the two approaches was less than 8 ̊, and this modest decrease in the working angle of the telovelar approach disappeared at the midpoint of the floor of the fourth ventricle. At the midpoint of the floor, the working angles of the two approaches more than doubled compared with the exposure at the aqueduct.
Compared with the transvermian approach, the telovelar approach provides equivalent exposure of the floor of the fourth ventricle and additional exposure of the superolateral recess and the foramen of Luschka, with only a modest decrease in working angles when approaching the rostral one fourth of the ventricle. Nevertheless, the exposure is achieved without removal of or incision through the functional areas of the cerebellum and may be associated with a lower incidence of mutism and other postoperative neurological sequelae.
Contributors: Necmettin Tanriover, MD, Arthur J. Ulm, MD, Albert L. Rhoton, Jr, MD, and Alexandre Yasuda, MD
This article was originally published here: Tanriover N, Ulm AJ, Rhoton AL, Jr, Yasuda A. Comparison of the transvermian and telovelar approaches to the fourth ventricle. J Neurosurg 2004;101:484–498, doi.org/10.3171/jns.2004.101.3.0484, and is included through an exclusive partnership with the Journal of Neurosurgery and its parent company, the American Association of Neurological Surgeons (AANS). The AANS retains full copyright. The appearance of this material here does not imply open access or free use by any other party.
The Neurosurgical Atlas is honored to maintain the legacy of Albert L. Rhoton, Jr, MD.
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