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Primary Central Nervous System Lymphoma (PCNSL)

Last Updated: October 1, 2018

Figure 1: The patchy and solid enhancement of lymphoma on postcontrast T1WI (top row left, top row right) and abutment of an ependymal surface is typical in immunocompetent patients. This lymphoma crosses the midline through the anterior body of the corpus callosum. Low T2 (bottom row left) and ADC (bottom row right) signal indicate hypercellularity. This lymphoma is also inciting a moderate amount of T2-hyperintense surrounding vasogenic edema.

 

Figure 2: This AIDS patient's inferior left frontal primary CNS lymphoma demonstrates a large amount of edema but is difficult to delineate on noncontrast CT (left). After administration of contrast (right), the centrally necrotic lesion is more apparent.

 

Figure 3: Corresponding MRI brain for patient in Figure 2. Axial T1 post-contras...