Vols. Videos

Glioblastoma (GBM)

Last Updated: October 1, 2018

Figure 1: The avid peripheral enhancement and central necrosis seen in this lesion on post-contrast T1WI (top row left) is typical of a glioblastoma. Infiltrative FLAIR (top row right) hyperintensity extending beyond the enhancing margins usually represent a combination of edema and nonenhancing infiltrative tumor. Areas of low signal intensity in regions of known tumor on ADC (bottom row left) usually indicate hypercellularity. Hemorrhagic foci are also not uncommonly seen on GRE or SWI (bottom row right) as in this patient's GBM.

Basic Description

  • Malignant, rapidly-enlarging astrocytic tumor with microvascular proliferation and necrosis
  • Most common primary intracranial neoplasm

Pathology

  • WHO grade IV
  • Necrosis and microvascular proliferation are characteristic features
  • Deve...