Last Updated: October 2, 2018
Arteriovenous malformations (AVMs) in pediatric patients are distinctly different from AVMs that present in adults. Pediatric AVMs are theorized to arise during embryogenesis due to genetic aberration and failure of differentiation of the vascular precursors.
This aberration is believed to occur during the third week of embryogenesis. However, this theory of pathogenesis is debated because of the known development of de novo AVMs and recurrence of AVMs following complete their removal as evidenced on angiography. These findings highlight the need for more basic science investigations into the pathogenesis, natural history, and epidemiology of these lesions.