Multiple Sclerosis (MS)
Last Updated: October 1, 2018
- Peak Age: 20-40
- Gender: F>M (1.7:1 F:M)
- Etiology: Not completely known. Viral and/or autoimmune mediated activation of T-cells which target myelin.
- Disease prevalence increases as distance north of equator increases.
- > 2 Million patients affected.
- Oligoclonal bands: positive
- Protein: normal (typically)
- IgG: elevated
- Cell count: Typically, normal (2/3 of patients); if significantly elevated (>50 cells/µl) consider other etiology.
McDonald Criteria: Diagnosis is made based on dissemination of lesions in space and time as determined by clinical findings alone or clinical findings in conjunction with imaging findings.
- Dissemination in space: Requires 1 or more lesions present in 2 or more MS-specific regions in the CNS (periventricular, juxtacortical, infratentorial, spinal cord) OR by progression of clinical symptoms implicating an additional site in the CNS.
- Dissemination in time: Simultaneous presence of enhancing and non-enhancing lesion on MRI, new T2/FLAIR hyperintense lesion on follow up MRI, or development of new clinical symptoms.
- Brain: Periventricular/perivenular, callososeptal interface, juxtacortical white matter/subcortical U-fibers, brachium pontis, brainstem.
- Spinal Cord:
- Cervical > thoracic cord
- Although most commonly dorsolateral aspect of cord, lesions are also often central and can be found anywhere.
- Typically seen in conjunction with brain lesions (90% of patients) but can be Isolated (10%).
- Nerves: Optic nerves. Involvement of other cranial nerves should raise suspicion for ADEM.
- Solitary or multifocal ovoid or wedge shaped T2 hyperintense lesions, asymmetric in distribution, most often located in the dorsolateral spinal cord.
- Length: Typically < 2 vertebral bodies in length (if > 2 vertebral bodies, consider NMO, ADEM, or idiopathic transverse myelitis)
- Width: Typically < ½ spinal cord in axial plane.
- Acute lesions: +/- mild cord swelling/edema which can mimic intramedullary neoplasm.
- Chronic Lesions: +/- cord atrophy, +/- residual STIR/T2 hyperintensity
Modality-Specific (Spinal Cord Only):
- CT Myelography:
- Spinal cord not well evaluated. May see spinal cord swelling in acute phase (mimics intramedullary tumor).
- T1: Isointense or hypointense.
- T1 + Contrast: +/- Enhancement. Ring, homogenous, or nodular enhancement in the subacute/acute phase. Typically resolves after 6 months.
- T2: Discrete or vague hyperintense lesions.
- STIR: Hyperintense lesions. Increased sensitivity for detection of lesions.
- DWI: Typically, increased diffusivity.
- Not typically utilized for spinal cord MS
- Decreased NAA, Increased Choline seen in areas of normal white matter.
- CT Myelography:
Contributor: Jacob A. Eitel, MD
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Rovira, Alex, Josephine Swanton, Mar Tintoré, Elena Huerga, Fredrick Barkhof, Massimo Filippi, Jette L. Frederiksen, et al. “A Single, Early Magnetic Resonance Imaging Study in the Diagnosis of Multiple Sclerosis.” Archives of Neurology 66, no. 5 (May 2009): 587–92. https://doi.org/10.1001/archneurol.2009.49.
Swanton, Josephine K., Alex Rovira, Mar Tintore, Daniel R. Altmann, Frederik Barkhof, Massimo Filippi, Elena Huerga, et al. “MRI Criteria for Multiple Sclerosis in Patients Presenting with Clinically Isolated Syndromes: A Multicentre Retrospective Study.” The Lancet. Neurology 6, no. 8 (August 2007): 677–86. https://doi.org/10.1016/S1474-4422(07)70176-X.
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