Vols. Videos

Acute Disseminated Encephalomyelitis (ADEM)

Last Updated: July 25, 2018

Figure 1: Sagittal STIR (top row left), sagittal T1 post-contrast fat-saturated (FS) (top row right), and axial T2 images of the thoracic spine demonstrate an expansile, T2/STIR hyperintense, intramedullary lesion with patchy enhancement in the thoracic spinal cord. The features are non-specific and the differential diagnosis includes both intramedullary neoplasm and demyelinating disease. However, with the given history of recent viral illness and clinical resolution following the treatment with steroids, the findings were most compatible with ADEM. 

Clinical Features

  • Peak Age: Childhood (5-8)
  • Gender: M > F (1:0.6-0.8)
  • Etiology: Post-infectious or post-vaccination immune-mediated demyelination

Imaging

  • General:
    • Location:
      • Brain/Brain stem: Multifocal subcortical/juxtr...