Last Updated: March 13, 2020
Trigeminal schwannomas are rare benign tumors representing the most common nonvestibular schwannoma, and 0.07 to 0.36% of all intracranial tumors. They may occur sporadically but case reports suggest patients with neurofibromatosis type 2 (NF-2) have an increased propensity to form these tumors in addition to the more commonly found vestibular schwannomas.
Schwannomas emerge from the peripheral nerve sheath, distal to the oligodendroglia–Schwann cell junction. The trigeminal nerve (cerebellpontine angle) and the gasserian ganglion (cavernous sinus and Meckel’s cave) are the most common sites for intracranial schwannomas after the vestibular nerve. Similar to vestibular schwannomas, gross total resection of a trigeminal schwannoma portends a good prognosis regarding long-term tumor free survival; however, if only partial resection is achieved, recurrence is common.
The operative approach and difficulty of resection is highly dependent on the location of the tumor along the trigeminal nerve. Jefferson’s classification proposed in 1959, which categorized the tumor based on the segment of the nerve affected. The Jefferson classification schema categorizes tumors into four types. Root type tumors are those arising from the nerve root and involve the posterior fossa. Ganglion type tumors are those that originate from the gasserian ganglion and are confined to the middle fossa. Dumbbell tumors are larger tumors involving the middle and posterior fossa. The fourth type of tumor is division tumors, which involve the V1, V2, or V3 segment of the trigeminal nerve.
Nerve root derived with posterior fossa involvement
Gasserian ganglion derived with middle fossa involvement
Combination posterior fossa-middle fossa involvement
Peripheral segment involvement
Patients with trigeminal schwannomas are nearly uniformly symptomatic with trigeminal nerve dysfunction at presentation. Symptoms typically include hypoesthesia within a variable distribution depending on the number of trigeminal segments affected. Keratitis can be an important feature heralding a loss of function within the trigeminal nerve due to the possible role of a diminished corneal reflex. Motor fibers of the nerve innervate the muscles of mastication including the tensor, digastric, and mylohyoid muscles with expected deficits in these muscles that are clinically rarely apparent. Trigeminal neuropathy follows an indolent course, corresponding to the slow-growth of the tumor.
Facial pain has also been reported in the setting of trigeminal schwannomas. The pain is different from the one experienced with trigeminal neuralgia. Although ticlike in onset, the long duration of pain and lack of a defined stimulus is characteristic of trigeminal schwannoma induced facial pain. These patients’ pain is also refractory to carbamazepine and other neuropathic pain medications used for trigeminal neuralgia. Despite this, the literature suggests that a small percentage of patients with trigeminal schwannomas experience pain consistent with the diagnosis of trigeminal neuralgia. All three divisions of the nerve are affected to different degrees at presentation.
Other presenting symptoms can be attributed to the mass effect on the surrounding cranial nerves. Deficits of facial motor, vestibular, and auditory function are possible with larger tumors. Diplopia is a result of compression on the oculomotor or abducens nerve, or from compression on the globe resulting in exophthalmos-related diplopia.
Patients with a trigeminal schwannoma should have a detailed neurologic examination with special consideration of trigeminal sensory and motor functions. A preoperative audiogram establishes the baseline functional status of cranial nerve (CN) VIII.
The complexity of the skull base anatomy relevant to resection of these tumors requires a thorough imaging evaluation. Magnetic resonance (MR) imaging characterizes the tumor’s size, degree of extension, and localizes the adjacent cranial nerves and cerebrovascular structures. Vestibular, facial and oculomotor schwannomas within the cerebellopontine angle can be difficult to differentiate from trigeminal schwannomas.
The radiographic evaluation includes computed tomography (CT) for defining the bony anatomy of the skull base and any resultant bony erosion. The proximity of the tumor to the carotid canal, cochlea, and internal auditory canal should be assessed to qualify the patient’s operative risk.
A CT angiogram defines the caliber of the involved arterial anatomy and elucidates the displacement of major vessels.
There are multiple management strategies for trigeminal schwannomas due to the benign slow-growing nature of these lesions. The most conservative approach is observation with serial imaging. This option includes a 6-12 month interval between the initial scans and is most applicable for patients with small tumors or elderly patients where the risk of surgery outweighs the risk of continued tumor growth.
Stereotactic radiosurgery is an option for small tumors with evidence of growth on serial imaging.
Microsurgical or endoscopic transnasal resection is the most definitive method of management for these lesions. If gross total resection is achieved, there is a low risk of recurrence, however, subtotal resection at the expense of preserving function can be supplemented with radiosurgery.
In the unique situation of bilateral trigeminal schwannomas, generally isolated to those patients with NF-2, the surgeon should only operate on the most symptomatic side. The contralateral nonsymptomatic tumor can be handled via observation or stereotactic radiosurgery.
Preoperative Considerations and Surgical Approach
The microsurgical or endoscopic approach utilized for trigeminal schwannomas is highly dependent upon the location of the tumor. The Jefferson’s classification simplifies the operative planning for these tumors. Table 2 lists the optimal surgical approaches for each type of tumor. Those tumors within the ganglion or peripheral category can be efficiently approached extradurally, to minimize the risk to adjacent cranial nerves.
|Extradural Subtemporal or Anterior Transpetrosal|
|Extradural Modified Orbitozygomatic|
Because of the soft consistency of trigeminal schwannomas, gross total removal of large, multicompartment tumors with a predominantly middle fossa component is achievable via a single extradural approach through the middle fossa. This principle also holds true for tumors that harbor predominantly a posterior fossa extension whose middle fossa component can be extracted via a modified retrosigmoid corridor and opening over the expanded Meckel’s cave.
However, the reach of the posterior fossa corridor into the middle fossa is very limited. Therefore, tumors with equally dominant middle and posterior fossa extensions should undergo first a middle fossa surgery with an attempt to remove the entire tumor; a second stage retrosigmoid craniotomy may be needed if the posterior fossa component cannot be safely resected at the initial operation.
A lumbar drain, or alternatively an external ventricular catheter is placed preoperatively to facilitate brain relaxation. The use of neurophysiologic monitoring augments the surgeon’s efforts to preserve function. These monitoring tools include somatosensory evoked potentials (SSEPs) and brain stem auditory evoked responses (BAERs).
The trigeminal nerve root originates from the lateral aspect of the rostral pons and travels superiorly, laterally, and anteriorly toward the petrous apex entering the Meckel's cave through the trigeminal impression, just inferior to the superior petrosal sinus. This first segment, which extends from the brainstem to the Meckel's cave, is referred to as the cisternal or cerebellopontine angle segment.
The root is myelinated by oligodendrocytes from its origin at the brainstem to the level of the central myelin–peripheral myelin transition zone, where the Schwann cells appear. Schwannomas arise from the peripheral myelin zone. After entering the trigeminal impression, the nerve courses within two leaflets of the dura, also known as the Meckel's cave.
Trigmeinal schwannomas involve the gasserian ganglion (middle fossa), the nerve root, (cerebellopontine angle) and the three divisions of the nerve (middle fossa). As expected, some tumors extend into more than one of these compartments and are typically dumbbell shaped. Rare tumors invade the extracranial space via the extracranial nerve branches in the orbit and infratemporal fossa. These tumors reach the orbit through the superior orbital fissure, and the infratemporal fossa through the foramen ovale or foramen rotundum.
The most frequent common tumor location is the middle cranial fossa (50%), followed by posterior fossa (30%) and dumbbell (20%) tumors. Extension into the cavernous sinus is common. These schwannomas do not infiltrate but rather displace their surrounding structures; therefore entry into the lateral cavernous sinus cavernous sinus for their removal is appropriate in most cases.
RESECTION OF TRIGEMINAL SCHWANNOMA
The Extended retrosigmoid approach applies to root type tumors within the cerebellopontine angle. This approach is described in detail within the Retrosigmoid Craniotomy chapter.
The suprameatal tubercle is just above the internal acoustic meatus and posterior to the trigeminal nerve. Upon removal of the dura from the surface of the suprameatal tubercle and drilling the tubercle, additional exposure along the trigeminal nerve and above it is secured. Although helpful, this approach is rarely necessary.
Orbitozygomatic and Subtemporal Approaches
The orbitozygomatic craniotomy is optimally used for schwannomas involving different segmental distribution of the trigeminal nerve within the cavernous sinus. For a more detailed discussion, refer to the Orbitozygomatic Craniotomy chapter. If the surgeon requires a wider operative field for approaching a V1 lesion, the optic canal can be unroofed and an extradural anterior clinoidectomy performed.
The technical nuances of the subtemporal craniotomy are discussed in the Temporal/Subtemporal Craniotomy chapter. The extradural modification to this approach provides a particular advantage for this type of tumor.
This route is flexible and reaches middle fossa lesions that extend into the posterior fossa via traversing the Meckel’s cave. If the caliber of Meckel’s cave is insufficient to gain access into the posterior fossa, the exposure can be expanded via an incision in the dura of the Meckel’s that continues toward the superior petrosal sinus. Through extracapsular and intra-arachnoidal dissection, the posterior fossa portion of the tumor can be resected.
This approach also permits entry into the cavernous sinus via its lateral wall for resection of enclosed tumors, which are generally the larger sized trigeminal schwannomas. One caveat is the need to identify the petrous ICA to provide proximal control over the cavernous segment during the dissection. Intracavernous dissection requires minimal manipulation of the adjacent cranial nerves to avoid postoperative deficits. The tumor is internally debulked and its capsule mobilized circumferentially after sufficient debulking. This technique requires microdissection of the capsule away from the adjacent trigeminal fascicles. Part of the trigeminal nerve that is incorporated into the tumor is resected.
The frontotemporal or pterional craniotomy is applicable for small trigeminal schwannomas. This approach is described in more detail within the pterional Craniotomy chapter.
Anterior Petrosectomy Approach
The extradural subtemporal anterior transpetrous approach is described in more detail within the Anterior Petrosectomy chapter. This operative pathway is optimized for large multicompartment lesions with involvement of both the posterior and middle fossae.
During the early postoperative period, the patient will experience trigeminal neuropathy due to intraoperative manipulation of the nerve. This dysfunction will demonstrate gradual improvement during the postoperative period. Diminution or loss of the corneal reflex is of particular concern acutely, due to the risk for keratitis if this deficit goes unnoticed and proper eye care is not implemented timely.
Surgery of the cavernous sinus often requires manipulation of CNs III, IV, and VI. Therefore, postoperative diplopia from paresis of one or all of these CNs is not uncommon. These deficits are also generally transient and will improve within 3 months.
Pearls and Pitfalls
- Trigeminal schwannomas are a heterogeneous group of tumors because of the significant variations in their size, shape and location.
- Familiarity with a wide variety of skull base approaches is necessary for their optimal management.
Contributor: Benjamin K. Hendricks, MD
For additional illustrations of the combined middle-posterior fossa approach to Meckel's cave, please refer to the Jackler Atlas by clicking on the image below:
For additional illustrations of the middle fossa approach to Meckel's cave, please refer to the Jackler Atlas by clicking on the image below:
For additional illustrations of the posterior fossa approach to Meckel's cave, please refer to the Jackler Atlas by clicking on the image below:
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Gragnaniello, C., Al-Mefty, O., Kondziolka, D., Kano, H., Lunsford L.D., Kawase, T. (2014) Total Removal of Trigeminal Schwannomas. In O. Al-Mefty (Ed.), Controversies in Neurosurgery II. New York, NY: Thieme Medical Publishers, Inc.
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Sekhar, L.N., Sarma, S., Schessel, D.A., Elahi, F. (2006) Nonvestibular Schwannomas of the Brain. In L.N. Sekhar & R.G. Fessler (Ed.), Atlas of Neurosurgical Techniques: Brain. New York, NY: Thieme Medical Publishers, Inc.
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