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Progressive Multifocal Leukoencephalopathy (PML)

Last Updated: October 1, 2018

Figure 1: This AIDS patients initial imaging demonstrates a linear, T1 hypointense (top row left), FLAIR hyperintense (top row right) region within the subcortical white matter of the left dorsolateral frontal lobe with associated volume loss. There was minimal associated peripheral reduced diffusivity (second row left) and no significant contrast enhancement (second row right). Little was known about the patient when they presented to the ER and given their recent onset symptoms, a diagnosis of subacute infarction was made.

Followup examinations over the next several months demonstrated significant interval increase in T1 hypointense (third row left), FLAIR hyperintense (third row right) signal abnormality within the subcortical white matter extending to the lateral ventricle. The degr...