Vols. Videos

Oligodendroglioma

Last Updated: October 1, 2018

Figure 1: This oligodendroglioma has internal coarse calcification on CT (top row left) that is very typical of this tumor. Coronal FLAIR (top row right) demonstrates typical fairly circumscribed permeative involvement of cortex and adjacent white matter. The mild hyperperfusion on this CBV image (bottom) is also seen fairly often in oligodendroglioma due to the pathologic feature of “chicken-wire” vascularity.

Basic Description

  • Slow-growing and infiltrating cortical/subcortical glial tumor

Pathology

  • WHO grade II
  • Anaplastic oligodendrogliomas (AO) are WHO III
  • Arises from malignant transformation of mature oligodendrocytes or glial precursor cells
  • calcification and cystic degeneration common
  • “Fried egg” microscopic appearance due to rounded nuclei and clear cytoplasm
  • Genetic...