Acute Disseminated Encephalomyelitis
- Autoimmune-mediated demyelination typically occurring shortly after immunization or upper respiratory viral infection
- Inflammation surrounding vessels, edema, and perivenous demyelination
- Fever, malaise, myalgia, lethargy, and potentially coma
- Nonspecific neurologic findings related to location of demyelination
- Most common in children
- Male > Female
- 10% to 30% mortality rate
- Multifocal areas of white matter demyelination typically within a few weeks of immunization or viral infection
- Cerebral, cerebellar, and spinal cord lesions
- Very little mass effect
- Modality specific
- Often normal at presentation but may have multiple ill-defined regions of hypoattenuation
- Variable enhancement
- Ill-defined regions of hypointensity
- Multifocal asymmetric white matter hyperintensities with surrounding edema
- Typically, symmetric signal abnormality within the basal ganglia and thalami
- Diffusion restriction is uncommon and portends a poor prognosis
- Incomplete rim of enhancement
- Cranial nerve enhancement is common
- Imaging Recommendations
- MRI with contrast of the brain and spinal cord
- While multiple sclerosis, vasculitis, and posterior reversible encephalopathy syndrome (PRES) are common mimics, acute disseminated encephalomyelitis (ADEM) can also mimic infiltrative glioma or CNS lymphoma in an immunocompromised patient, particularly when involving the corpus callosum. The incomplete rim of enhancement and clinical history of recent immunization or upper respiratory tract infection can help clinch the diagnosis.
Contributors: Sean Dodson, MD, and Jacob A. Eitel, MD
Honkaniemi J, Dastidar P, Kähärä V, et al. Delayed MR imaging changes in acute disseminated encephalomyelitis. AJNR Am J Neuroradiol 2001;22:1117–1124.
Kanekar S, Devgun P. A pattern approach to focal white matter hyperintensities on magnetic resonance imaging. Radiol Clin North Am 2014;52:241–261.
Mader I, Stock KW, Ettlin T, et al. Acute disseminated encephalomyelitis: MR and CT features. AJNR Am J Neuroradiol 1996;17:104–109.
Noorbakhsh F, et al. Acute Disseminated Encephalomyelitis: Clinical and Pathogenesis Features. 2008;26:759–780.
Rossi A. Imaging of acute disseminated encephalomyelitis. Neuroimaging Clin N Am 2008;18:149–161. doi.org/10.1016/j.nic.2007.12.007
Please login to post a comment.