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Metastasis

Last Updated: September 28, 2018

Frontal Metastasis: Principles of Resection

A metastatic brain tumor originates from a primary tumor derived from tissue outside the central nervous system (CNS) or the surrounding meninges. The tumor secondarily disperses to involve the cranium, meninges, or brain parenchyma. 

Figure 1: Metastatic tumors typically occur at the gray-white matter junction and lead to significant white matter edema (out of proportion to the size of the lesion). Multiplicity is frequently observed and larger lesions with significant mass effect/edema among patients with a reasonable life span and controlled systemic disease are candidates for resection.

Treatment of metastatic brain lesions has a history of contention with regard to its surgical indications. However, with recent improvements in imaging...