Vols. Videos

Cryptococcosis

Last Updated: October 1, 2018

Figure 1: In this HIV positive patient, there is a cluster of dilated perivascular spaces and pseudocysts with signal isointense to CSF on T1 (top row left), T2 (top row right) and FLAIR (middle row left). The medial most lesion demonstrated more heterogeneous signal with a solid enhancing component (middle row right) along the medial margin. The majority of these lesions in the basal ganglia demonstrate normal or increased diffusivity on DWI/ADC (bottom row), a common finding in many atypical infections.

Description

  • Opportunistic fungal infection (Cryptococcus neoformans)
  • Strongest risk factor is T-cell dysfunction, thus most commonly seen in patients with HIV/AIDS

Pathology

  • Encapsulated, yeast-like fungus that is found in animal droppings
  • Infection in the lung spreads throug...