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Subependymal Giant Cell Astrocytoma (SEGA)

Last Updated: October 1, 2018

Figure 1: This subependymal giant-cell astrocytoma (SEGA) is present in its typical location at the foramen of Monro. This lesion is larger than should be seen for other subependymal nodules in tuberous sclerosis. The FLAIR image (left) demonstrates multiple subcortical hyperintense tubers. A hyperintense right posterior periventricular nodule is also visible. Other calcified subependymal nodules are less evident. Postcontrast T1WI (right) demonstrates the avid enhancement typical of SEGAs.

Basic Description

  • Benign tumor of neuroglial origin classically arising in patients with tuberous sclerosis complex (TSC)
  • Slow-growing tumor arising in region of germinal matrix, usually near the foramen of Monro where it may obstruct ventricular outflow resulting in noncommunicating hydrocephalu...