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Immune Reconstitution Inflammatory Syndrome (IRIS)

Last Updated: October 1, 2018

Figure 1: The images above are from an HIV positive patient with low CD4 count. The initial imaging demonstrated left dorsolateral frontal T1 hypointense (top row left), FLAIR hyperintense (top row right) signal that extends through the white matter even to involve the subcortical U fibers, findings that represent PML. The initial imaging was without abnormal enhancement. Six weeks after initiating HAART, the patient developed worsened neurologic deficits and shortly thereafter became obtunded. Followup imaging demonstrated significant interval worsening in the almost mass-like T1 hypointense signal (middle row right) with corresponding FLAIR hyperintense signal (bottom row left), increased mass effect with near complete effacement of the left lateral ventricle and mild left-to-right mid...