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Management

Last Updated: September 27, 2018

Equivalent Corticosteroid Doses
Quick reference guide for corticosteroid comparison
Generic Steroid Equivalent dose (mg) Anti-inflammatory Potency Mineralocorticoid potency Oral dosing forms (tablet in mg) Duration of Action (hours)
Cortisone 25 0.8 0.8 tab: 25 8-12
Hydrocortisone 20 1 1 tab: 5, 10, 20 8-12
Prednisone 5 4 0.8 tab: 1, 2.5, 5, 10, 20, 50 12-36
Prednisolone 5 4 0.8 tab: 10, 15, 30 12-36
Methylprednisolone 4 5 0.5 tab: 4, 8, 16, 32 12-36
Dexamethasone 0.75 30 0 tab: 0.5, 0.75, 1, 1.5, 2, 4, 6 36-54
Betamethasone 0.6 30 0 solution: 0.6mg/5ml (118mL) 36-54
Fludrocortisone - 15 150 tab: 0.1mg 24-36
  • Potencies are reported relative to hydrocortisone
  • Steroid doses are listed for equivalent glucocorticoid PO / IV doses (IM may differ)
Initial Steps for Status Epilepticus Therapy (Adult)
AED Step Description
1st Line Lorazepam 0.1mg/kg IV @ <2mg/min
2nd Line

Give either simultaneously with above or 1 minute after lorazepam infusion completes:

  1. phenytoin 20mg/kg IV @ <50mg/min
  2. phosphenytoin 20mg/kg IV @ <150mg/min
3rd Line

7% chance of success at stopping seizure:

  1. phenobarbital <20mg/kg IV @ <100mg/min
  2. valproate 15-30mg/kg IV @ <6mg/...
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