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Neurofibromatosis Type 1 (NF1)

Last Updated: October 1, 2018

Figure 1: Though associated with many tumors, these NF lesions are merely tumor mimics. Notice the FLAIR-hyperintense (left) nonenhancing (right) abnormalities within the globus pallidi and to a lesser extent the dorsal thalami - compatible with focal areas of signal intensity (FASI). These regions can be seen in the basal ganglia, thalami, brainstem, cerebellum, or subcortical white matter.

 

Figure 2: Axial FLAIR images through the basal ganglia (top row left) and pons (top row right) demonstrate expansile hyperintense lesions most compatible with NF dysplasias, a tumor mimic. Low grade tumors may also be present in NF 1, including optic nerve glioma seen as right greater than left optic nerve enlargement on coronal T2FS (bottom row left) and sagittal T1 post-contrast (bottom row r...