Endoscopic Expanded Transnasal Approach
Endoscopic transnasal surgery has revolutionized our operative philosophy for many challenging and difficult-to-reach skull base tumors. An understanding of the technical nuances of approach or “how to get there” is important for the skull base neurosurgeon to work as part of the team with the rhinologist to ensure adequate exposure for the tumor is secured. Overall, the transnasal approach remains in the territory of our rhinology colleagues.
I will review the nuances of the technique for the expanded transnasal exposure to the anterior skull base in this section. Suprasellar meningiomas, craniopharyngiomas, and other third ventricular lesions are suitable candidates for this approach.
I prefer to remove moderate size olfactory groove meningiomas (with the goal of saving preoperative functional olfaction) through a supraorbital craniotomy and an eyebrow incision. Although some colleagues have used the transnasal corridor for most olfactory groove meningiomas, the opportunity for saving olfaction is not feasible via this route, especially for moderate size meningiomas. Large and giant meningiomas are removed through an extended pterional craniotomy. I do not recommend the use of a bifrontal craniotomy.
ENDOSCOPIC EXPANDED TRANSNASAL APPROACH
Following induction of general anesthesia, preoperative antibiotics and a stress dose of methylprednisolone/dexamethasone are administered.
For routine pituitary tumor operations, I do not use a lumbar drain. However, I routinely place a lumbar drain for expanded skull base osteotomies for intradural non-adenomatous tumors. I clamp the drain for the duration of the operation and may use it for intrathecal administration of fluorescein. The patient’s head is placed either on a donut gel rest or in rigid pin fixation with the patient’s neck slightly extended and the head raised just above the level of the heart. Frameless stereotactic neuronavigation is registered using preoperative computed tomography (CT) and magnetic resonance imaging (MRI). A fascia lata donor site and abdominal fat donor site are prepared in anticipation of cranial base reconstruction. Routine nasal mucosal preparation is performed.
Following disconnection of the nasoseptal flap using monopolar electrocautery and its mobilization using blunt dissection, the mucosal side of the septal vascularized flap is pushed into the nasopharynx until tumor resection is complete, with the operator taking care to prevent twisting of its pedicle and resultant ischemia. The operation proceeds with a binostril technique in which one surgeon works bimanually while another drives the endoscope, using dynamic visualization to facilitate 3-dimensional perception of the surgical field. The use of an endoscope holder is an alternative technique, but not preferred since it prevents dynamic motion of the scope for advanced visualization.
The initial phase of the approach consists of lateral mobilization of the middle and inferior turbinates bilaterally, identifying the sphenoid ostia, performing a posterior septectomy, creating a wide sphenoidotomy, removing the sphenoid mucosa, performing partial posterior ethmoidectomies, and drilling the bony septations in the sphenoid sinus. The middle turbinate may be removed on one side to accommodate the endoscope to prevent its interference with manipulation of the instruments, but often the turbinates can be preserved. The above steps are tailored based on the underlying pathology.
A wide sphenoidotomy is important for the remainder of the operation because it allows greater degrees of operative freedom for passage and manipulation of instruments in the deep operative fields above the chiasm, and it minimizes the potential for instrument/endoscope collision or “sword fighting.” If both opticocarotid recesses cannot be readily seen with a 0-degree scope, the lateral exposure is inadequate. Variations in septal (septum deviation) or sphenoid sinus (multiseptated) anatomy can affect the extent of the septectomy and sphenoid sinus resection.
The lateral aspects of the surgical corridor should be limited by the nasal turbinates rather than by remnants of the anterior sphenoid wall. Posterior ethmoidectomy fully exposes the planum sphenoidale, and although the lesion may not extend to this level, this maneuver expands the operative corridor, widens the working angles, and prevents overhanging bone from impeding visualization and manipulation of instruments.
Complete removal of the sphenoid mucosa prevents formation of a postoperative mucocele, reveals important bony landmarks necessary for subsequent steps in the procedure, and provides the necessary bony substrate for adhesion of the pedicled nasoseptal flap.
All the above steps, including the elevation of the nasoseptal flap, are not necessary for common pituitary tumors and posterior ethmoidectomy has to be tailored for the individual tumor.
There is osteological and morphological variation along the floor of the parasellar skull base. Unfortunately, the medial opticocarotid recess is not always visible, so the lateral opticocarotid recess and bony prominences over the carotid artery can be used to estimate the location of the medial opticocarotid recess. The sella is usually easily identified between the bilateral carotid artery prominences. The clival recess is visible inferior to the sella. If the sphenoid sinus is not well pneumatized, as in young children, these landmarks may be quite difficult to recognize, necessitating sole reliance on navigation and careful thinning of the bone until the landmarks can be reliably established.
A high-speed diamond-bit drill (or an ultrasonic curette) is used to remove bone over the sella turcica, tuberculum sellae, and posterior portion of the planum sphenoidale. Bone removal extends laterally to the medial opticocarotid recesses. The bone is initially shelled out or thinned using the drill and then removed using a Kerrison rongeur. I use copious amount of irrigation while drilling over the medial opticocarotid recesses to prevent thermal injury to the optic nerve. These nerves can be displaced and easily injured if not looked for and protected at all times.
Venous bleeding is often encountered upon removal of bone in this area, but even vigorous venous bleeding is usually easily controlled with gelfoam packing and gentle pressure. I use an ample amount of Floseal hemostatic matrix (Baxter, Deerfield, IL) to seal the bleeding from the cavernous sinus and other venous lakes in the exposed dura. The extent of bony exposure in the sagittal plane is determined by the size and location of the tumor along the same plane, and can be guided intraoperatively by using neuronavigation.
Tumors confined to the sella require removal of the anterior sellar wall, whereas preinfundibular tumors within the suprasellar cistern require more bony removal over the tuberculum sellae and the planum sphenoidale and less removal of the inferior/anterior sellar wall. However, it is recommended that the operator removes the bone above and below the superior intercavernous sinus to control and transect this vascular structure in order to open the diaphragma sella, which lies just behind this sinus.
Transinfundibular tumors often extend superiorly into the anterior third ventricle, and their exposure requires excision of additional bone over the anterior sella to accommodate the steeper working angles required to reach the superior ventricular extent of these lesions. Retroinfundibular tumors necessitate removal of the sellar floor along the inferior intercavernous sinus and occasionally along the posterior clinoid processes and dorsum sella.
More aggressive skull base osteotomies allow exposure and resection of tumors extending from the infundibulum into the prepontine and interpeduncular cisterns, as well as lateral transposition of the pituitary gland as needed. Alternatively, an “above and below” approach may be performed to reach both above and behind the sella. Transclival approaches require variable clivectomy based on the breadth of the tumor.
The distinctions among the tumor types mentioned above and in the following chapters are not absolute because most tumors occupy more than one of these anatomic compartments. The anterior extent of bony opening along the posterior planum sphenoidale does not need to expand significantly since most dissection, especially in the case of a craniopharyngioma, is carried out beneath the chiasm. However, if the tumor extends markedly above the chiasm, requiring a translamina terminalis approach, additional bone resection along the planum may be needed to allow a more direct working angle to the region.
Following adequate bone removal as confirmed by navigation, the superior intercavernous sinus is coagulated, and the dura is opened in a cruciate fashion. The dural edges are cauterized and shrunk to increase visualization. It is also possible to excise the dural edges using Kerrison rongeurs to expand the operative corridor. Before dural opening, microdoppler ultrasonography is routinely used to avoid injury to the ICA, especially since its proximal supraclinoid segment courses medially.
During later steps of the exposure and subsequent resection, use of a 30-degree angled endoscope may be preferable so that the tip of the endoscope may be moved out of the working zone of the surgical instruments while the operator maintains adequate visualization.
The exposure and osteotomy should be conducted with the plans of closure in mind. Cerebrospinal leakage remains one of the unconquered challenges in transnasal skull base surgery.
The patient is observed in the intensive care unit overnight for frequent neurologic evaluations and pain/blood pressure control. I open the lumbar drain on the first postoperative day and remove 5-10cc/hour. The lumbar drain is discontinued ~2-4 days after surgery to facilitate early mobilization. A postoperative MRI is obtained.
Steroids may be slowly weaned as tolerated by the patient. Prophylactic anticonvulsants may be administered perioperatively, but tapered off 1 week after surgery if the patient has not suffered a seizure. Routine postoperative antibiotics are continued while the drain is in place. Monitoring of urine output and serum sodium allows management of temporary postoperative diabetes insipidus. Standard endonasal precautions are recommended to the patient, including avoidance of nose-blowing, straw use, and unnecessary bearing down.
Pearls and Pitfalls
- A thorough understanding of the parasellar skull base anatomy is important for safe completion of the bone work.
- For most suprasellar nonadenomatous pathologies, I remove only the anterior half of the rostrum; this minimal bone removal protects the pituitary gland and facilitates watertight skull base reconstruction at the end of tumor resection.
For additional illustrations of using endoscopes during skull base surgery, please refer to the Jackler Atlas by clicking on the image below:
Conger AR, Lucas J, Zada G, Schwartz TH, Cohen-Gadol AA. Endoscopic extended transsphenoidal resection of craniopharyngiomas: nuances of neurosurgical technique. Neurosurgical Focus. 37(4):E10, 2014.
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