Teratoma

Figure 1: This complex pineal-region teratoma demonstrates areas of solid and cystic change and calcification on CT (top left) and areas of hyperintense fat signal intensity on the T1-weighted MR image (top right). Heterogeneous enhancement is a hallmark finding that illustrates the complexity of teratomas on T1 after contrast administration (bottom). Basic Description Midline intracranial tumor arising from multipotential germ cells Pathology Contains tissue from all three germ cell types: ectoderm, endoderm, and mesoderm Fat, calcification, teeth, soft tissue, sebaceum, and cysts Three types Mature: well-differentiated, WHO grade 1, often with cystic tumor component Immature: intermediate differentiation Malignant: malignant degeneration of immature teratoma, may contain somatic tumors Clinical Features Arises during fetal development due to aberrant formation of the primitive streak Mean patient age at diagnosis 15 years; may be detected on feta...

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