Anaplastic Astrocytoma (AA)

Figure 1: Axial FLAIR (top row left) demonstrates a left insular infiltrative lesion involving the cortex and white matter. This anaplastic astrocytoma is fairly circumscribed, a less common characteristic in these higher grade lesions. ADC (top row right) demonstrates no appreciable dark restricted diffusion in this lesion to suggest hypercellularity. Axial T1WI post contrast (bottom) shows a small round area of enhancement in the superficial insula, a feature more typical of higher grade glioma. If the T2/FLAIR hyperintensity surrounding this lesion spared the cortex, the enhancing lesion may be more easily mistaken for metastasis with surrounding vasogenic edema. Basic Description Infiltrating malignant astrocytoma with ill-defined tumor margins and extensive edema Pathology WHO grade III Usually develops from malignant degeneration of low-grade astrocytoma (WHO II) Commonly dedifferentiates into GBM (~50%) within 2 years Focal or diffuse anaplasia, highly proliferativ...

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