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Inferior View of the Septal and Hypothalamic Regions

Surgical Correlation

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Inferior view of the septal region, anterior commissure and hypothalamus. The diagonal band of Broca connects the subcallosal gyrus of the septal area to the amygdala and hippocampus, and forms the posteromedial margin of the anterior perforated substance. The stria terminalis is the major output pathway of the amygdala and projects mainly to the hypothalamus and septal region.  The C-shaped stria terminalis runs caudally in the roof of the inferior horn of the lateral ventricle, then turns rostrally (disappearing from view in this dissection) to run forward, dorsolateral to the thalamus, within the floor of the body of the lateral ventricle.  The mammillary bodies are located in the posterior region of the hypothalamus and form the posterior floor of the third ventricle. The medial forebrain bundle interconnects the hypothalamus and the septal region and basal forebrain and is part of the brain's reward and pleasure circuitry. The anterior commissure crosses the midline just anterior to the hypothalamus before coursing laterally and inferiorly, indenting the inferior surfaces of the lenticular nuclei, to interconnect the middle and inferior temporal gyri. (Image courtesy of AL Rhoton, Jr.)

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